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HLA-DRB5 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 217021AP

Catalog No. 50-173-3554


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Description

Description

HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Specifications

Specifications

HLA-DRB5
0.17 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q30154
DR beta 2, DR beta 5, Dw2, HLA DRB, HLA DRB5, HLA-DRB5, MHC class II antigen DRB5
Rabbit
IgG
150 μL
-20°C
Primary
3127
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
HLA-DRB5
Liquid
HLA-DRB5
HLA-DRB5 Fusion Protein Ag16307
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Documents
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