HMGCR Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Catalog No.	Quantity
50-172-8814	150 μL

Catalog No. 50-172-8814 Supplier Proteintech Group Inc Supplier No. 135331AP150UL

Description

Rabbit Polyclonal Antibody

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determit of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: HMGCR
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.23 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: HMGCR
• Gene Accession No.: P04035, P51639, Q01237
• Gene Alias: HMG CoA reductase, HMGCR
• Gene Symbols: HMGCR
• Host Species: Rabbit
• Immunogen: HMGCR Fusion Protein Ag4444
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 15357, 25675, 3156
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG