HMGCR Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-8814	Proteintech Group Inc 135331AP150UL	150 μL

Description

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determit of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: HMGCR
• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: P04035, P51639, Q01237
• Gene ID (Entrez): 15357, 25675, 3156
• Immunogen: HMGCR Fusion Protein Ag4444
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: HMGCR

• Concentration: 0.23 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: HMG CoA reductase, HMGCR
• Gene Symbols: HMGCR
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody