DescriptionmiRNA mimics are small, chemically modified double-stranded RNA molecules designed to specifically bind to and mimic endogenous miRNA molecules and enable miRNA functional analysis by up-regulation of miRNA activity.
We have now released the second generation of miRNA mimics,mirVana miRNA Mimics which:
- Exhibit maximum and consistent effect in vitro at low concentration
- Are non toxic
- Offer superior specificity due to unique Star strand modification
- Target the most updated Sanger content
- Can be used in vitro and in vivo, offering you consistency throughout your entire research project
Positive and negative controls are also available for use along with mirVana miRNA Mimics in miRNA up-regulation experiments.
mirVana miRNA Mimic miR-1 Positive Control
The mirVana miRNA Mimic miR-1 Positive Control is designed to mimic mature miR-1 miRNA after delivery to mammalian cells. miR-1 is associated with down-regulation of many genes. In particular, miR-1-mediated down-regulation of Protein Tyrosine Kinase 9 (PTK9) has been shown to occur at the mRNA level. miR-1 Positive Control is intended for use as a positive control for transfection experiments using mirVana miRNA Mimics. Monitor activity of miR-1 Positive Control through its gene silencing of PTK9, using real-time reverse transcription-PCR to detect PTK9 mRNA.
First Generation Mimic Controls
Our first-generation miRNA mimics (and controls), Ambion Pre-miR miRNA Precursors, have lower specificity and potency, plus a lower strand specificity compared to the new mirVana miRNA Mimics. These first-generation mimics are recommended for completing ongoing in vitro miRNA studies. For new studies or in vivo studies, we highly recommend our new mirVana miRNA Mimics and their corresponding controls.
|miRNA and non-coding RNA analysis|
For Research Use Only. Not for use in diagnostic procedures.
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