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  8. ICA 121431, Tocris Bioscience™ 

ICA 121431, Tocris Bioscience™ Available on GSA/VA Contract for Federal Government customers only.

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Quantity:
10mg
50mg
This item is not returnable. View return policy
313254-51-2
C23H19N3O3S2
449.543
URSQNPPONHUJDL-UHFFFAOYSA-N
2,2-diphenyl-n-4-n-thiazol-2-yl sulfamoyl phenyl acetamide,2,2-diphenyl-n-4-1,3-thiazol-2-ylsulfamoyl phenyl acetamide,2,2-diphenyl-n-4-thiazol-2-ylsulfamoyl-phenyl-acetamide,2,2-diphenyl-n-4-1,3-thiazol-2-yl sulfamoyl phenyl acetamide,2,2-diphenyl-n-4-1,3-thiazol-2-ylamino sulfonyl phenyl acetamide,alpha-phenyl-n-4-2-thiazolylamino sulfonyl phenyl-benzeneacetamide
998021
2,2-diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide
C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CS4
This item is not returnable. View return policy
313254-51-2
C23H19N3O3S2
449.543
URSQNPPONHUJDL-UHFFFAOYSA-N
2,2-diphenyl-n-4-n-thiazol-2-yl sulfamoyl phenyl acetamide,2,2-diphenyl-n-4-1,3-thiazol-2-ylsulfamoyl phenyl acetamide,2,2-diphenyl-n-4-thiazol-2-ylsulfamoyl-phenyl-acetamide,2,2-diphenyl-n-4-1,3-thiazol-2-yl sulfamoyl phenyl acetamide,2,2-diphenyl-n-4-1,3-thiazol-2-ylamino sulfonyl phenyl acetamide,alpha-phenyl-n-4-2-thiazolylamino sulfonyl phenyl-benzeneacetamide
998021
2,2-diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide
C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CS4

Description

Potent and selective NaV1.3 and NaV1.1 channel blocker

Potent and selective inhibitor of human NaV1.3 and NaV1.1 channels (IC50 values are 13 and 23 nM respectively). Exhibits up to 1,000 fold selectivity against other TTX-sensitive or resistant sodium channels (IC50 values are >10 μM for human NaV1.5 and NaV1.8 channels). Interacts with an inhibitory interaction site distinct from those bound by TTX and local anesthetic-like modulators.

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Quantity 10mg
Color White
Formula Weight 449.55
Physical Form Solid
Percent Purity >98%
Chemical Name or Material ICA 121431

Safety and Handling

Recommended Storage : Store at +4°C