ICAM-1/CD54 Antibody (W-CAM-1 (same as Wehi-CAM-1 or 1H4)) - IHC-Prediluted, Novus Biologicals™

Catalog No.	Quantity
NBP248214	7 mL

Catalog No. NBP248214 Supplier Novus Biologicals Supplier No. NBP248214

Description

Mouse Monoclonal Antibody

ICAM-1/CD54 Monoclonal specifically detects ICAM-1/CD54 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: ICAM-1/CD54
• Applications: Immunohistochemistry (Paraffin)
• Classification: Monoclonal
• Clone: W-CAM-1 (same as Wehi-CAM-1 or 1H4)
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry-Paraffin
• Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
• Gene Alias: BB2, CD54, CD54 antigen, cell surface glycoprotein P3.58, human rhinovirus receptor, ICAM-1, intercellular adhesion molecule 1, intercellular adhesion molecule 1 (CD54), human rhinovirus receptor, Major group rhinovirus receptor, P3.58
• Gene Symbols: ICAM1
• Host Species: Mouse
• Immunogen: Raji Burkitt lymphoma cells
• Purification Method: Protein A or G purified
• Quantity: 7 mL
• Regulatory Status: RUO
• Research Discipline: Adaptive Immunity, Cancer, Cell Biology, Immunology, Mesenchymal Stem Cell Markers, Myeloid derived Suppressor Cell, Stem Cell Markers
• Primary or Secondary: Primary
• Gene ID (Entrez): 3383
• Test Specificity: Recognizes an 85-115kDa protein (variation with cell type), identified as intercellular adhesion molecule (ICAM-1) (Workshop IV). It has 7 potential N-linked glycosylation sites. ICAM-1 is a single chain glycoprotein of Ig supergene family, present on unstimulated endothelial cells (EC) and on a variety of other cell types including activated fibroblasts, EC, macrophages, and lymphocytes. ICAM-1 mediates cell adhesion by binding to integrins CD11a/CD18 (leukocyte adhesion molecule, LFA-1) and to CD11b/CD18 (Mac-1). This interaction enhances antigen-specific T-cell activation. ICAM-1 also binds to CD43 and to Plasmodium falciparum infected RBCs. W-CAM-1 monoclonal antibody blocks aggregation of cell lines mediated by the ICAM-1 and blocks homotypic binding of Purified populations of activated T- and B-lymphocytes and also aggregation of mixed T- and B-cell blasts. It inhibits T-cell adhesion to normal human endothelial cells. Activation induced by cell-cell contact (mixed lymphocyte reaction, T-cell mediated B-cell activation) is significantly inhibited. This monoclonal antibody blocks elements of both effector arms of immune system (cytotoxic cell function and Ig production).
• Target Species: Human
• Content And Storage: Store at 4C.
• Form: Purified
• Isotype: IgG2b κ