IFN-γ Mouse anti-Human, PE, Clone: B27, BD

Catalog No.	Quantity
BDB562016	25 Tests
BDB559327	100 Tests

Catalog No. BDB562016 Supplier BD Biosciences Supplier No. 562016

Description

Mouse Monoclonal Antibody

The B27 monoclonal antibody specifically binds to human interferon- γ(IFN- γ). IFN-γis a potent multifunctional cytokine that is produced by several activated cell types including NK, NKT, CD4+TCRαβ+, CD8+TCRαβ+, and TCRγδ + T cells. IFN- γexerts i ts biological effects through specific binding to the high-affinity IFN- γReceptor Complex comprised of IFN- γβ subunits. In addition to its antiviral effects, IFN- γupregulates a number of lymphoid cell functions including the antimicrobial and antitumor responses of macrophages, NK cells, and neutrophils. In addition, IFN- γcan exert strong regulatory influences on the proliferation, differentiation, and effector responses of B cell and T cell subsets. Th ese influences can involve IFN- γ’s capacity to boost MHC class I and II expression by antigen-presenting cells as well as to direct effects on B cells and T cells t hemselves. Human IFN-γis a 14- 18 kDa glycoprotein containing 143 amino acid residues. B27 is a neutralizing antibody. The use of B27 antibody for epitope mapping of human IFN- γhas been described. The B27 antibody has been reported not to bind to denatured IFN- γ.

Specifications

• Antigen: IFN-γ
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: B27
• Conjugate: PE
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Human IFN-γ Recombinant Protein
• Purification Method: Affinity Purified
• Quantity: 25 Tests
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Isotype: IgG1 κ

For Research Use Only.