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Invitrogen™ IgE Monoclonal Antibody (Ige21), NovaFluor™ Blue 510, eBioscience™, Invitrogen™

Catalog No. p-200026004
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H077T03B01A 100 Tests
H077T02B01A 25 Tests
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Catalog No. H077T03B01A Supplier Invitrogen™ Supplier No. H077T03B01A
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Description

Mouse Monoclonal Antibody

IgE is one of the five classes of immunoglobulins found in mammals, characterized by its monomeric structure consisting of two heavy (epsilon) chains with four Ig-like constant domains and two light chains. Although IgE comprises only a small portion of the total immunoglobulin in serum, it plays a crucial role in type I hypersensitivity reactions, such as hay fever, asthma, hives, and anaphylactic shock. IgE is produced by terminally differentiated plasma B cells and basophils. It binds to Fc epsilon receptors on mast cells and basophils, leading to the release of histamine and other molecules that promote allergic responses. Crosslinking of IgE bound to these receptors induces degranulation of mast cells and basophils, resulting in allergic manifestations. In addition to its role in allergic responses, IgE is functionally important for immunity against parasites, highlighting its dual role in both protective and pathological immune processes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Human IgE
Applications Flow Cytometry
Classification Monoclonal
Clone Ige21
Concentration 0.2 μg/Test
Conjugate NovaFluor Blue 510
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene IGHE
Gene Accession No. P01854
Gene Alias HCAK1; IgA1; IgG3; IGHA1; IGHA2; IGHG1; IGHG2; IGHG3; IGHG4; IGKC; IGKCD; IGLC; IGLC1; Immunoglobulin E; immunoglobulin heavy constant alpha 1; immunoglobulin heavy constant alpha 2 (A2m marker); immunoglobulin heavy constant gamma 1 (G1m marker); immunoglobulin heavy constant gamma 2 (G2m marker); immunoglobulin heavy constant gamma 3 (G3m marker); immunoglobulin heavy constant gamma 4 (G4m marker); immunoglobulin kappa constant; immunoglobulin lambda constant 1; ImmunoglobulinE; Km
Gene Symbols IGHE
Host Species Mouse
Purification Method Affinity chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3497
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG1 κ
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