Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Invitrogen™ IL-17AF Monoclonal Antibody (1402nAF), Functional Grade, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Supplier: Invitrogen™ 16917238
Description
Description: The 1402nAF monoclonal antibody reacts with mouse interleukin (IL)-17AF heterodimer. This antibody specifically reacts with this heterodimer and has no reactivity for IL-17A or IL-17F homodimers. Applications Reported: This 1402nAF antibody has been reported for use as a neutralization antibody of IL-17AF biological activity. Applications Tested: The Functional Grade purified format of the 1402nAF antibody has been tested for neutralization of IL-17AF biological activity. Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC.
IL-17A and IL-17F are well-characterized homodimeric cytokines secreted by T helper 17 (Th17) cells, gamma-delta T cells and several subsets of innate lymphoid cells. Somewhat less appreciated, IL-17A and IL-17F subunits can also form the heterodimer, IL-17AF. Together, these three dimers signal through the IL-17RA/IL-17RC receptor complex to mediate immune responses at mucosal interfaces and are found at lesion sites in inflammatory bowel disease, asthma, atopic dermatitis and rheumatoid arthritis.
Specifications
| IL-17AF | |
| Monoclonal | |
| 1.0 mg/mL | |
| PBS with no preservative; pH 7.2 | |
| Q62386, Q7TNI7 | |
| Il17a, Il17f | |
| Affinity chromatography | |
| RUO | |
| 16171, 257630 | |
| 4°C, do not freeze | |
| Liquid |
| Functional Assay, Neutralization | |
| 1402nAF | |
| Functional Grade | |
| Il17a | |
| C87042; CANDF6; Ctla8; CTLA-8; cytokine ML-1; Cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; IL17; IL-17; Il17a; IL-17A; IL17F; IL-17F; ILN; Interleukin; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A; interleukin 17F; interleukin-17A; Interleukin-17F; ML1; ML-1 | |
| Rat | |
| 5 mg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG2a κ |
Safety and Handling
WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov
Product Content Correction
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction