IL-17AF Monoclonal Antibody (1402nAF), Functional Grade, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
16-917-238	Invitrogen™ 16917238	5 mg

Description

Description: The 1402nAF monoclonal antibody reacts with mouse interleukin (IL)-17AF heterodimer. This antibody specifically reacts with this heterodimer and has no reactivity for IL-17A or IL-17F homodimers. Applications Reported: This 1402nAF antibody has been reported for use as a neutralization antibody of IL-17AF biological activity. Applications Tested: The Functional Grade purified format of the 1402nAF antibody has been tested for neutralization of IL-17AF biological activity. Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC.

IL-17A and IL-17F are well-characterized homodimeric cytokines secreted by T helper 17 (Th17) cells, gamma-delta T cells and several subsets of innate lymphoid cells. Somewhat less appreciated, IL-17A and IL-17F subunits can also form the heterodimer, IL-17AF. Together, these three dimers signal through the IL-17RA/IL-17RC receptor complex to mediate immune responses at mucosal interfaces and are found at lesion sites in inflammatory bowel disease, asthma, atopic dermatitis and rheumatoid arthritis.

Specifications

• Antigen: IL-17AF
• Concentration: 1.0 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with no preservative; pH 7.2
• Gene ID (Entrez): 16171, 257630
• Primary or Secondary: Primary
• Content And Storage: 4°C, do not freeze

• Clone: 1402nAF
• Applications: Functional Assay, Neutralization
• Conjugate: Functional Grade
• Host Species: Rat
• Target Species: Mouse
• Gene Accession No.: Q62386, Q7TNI7
• Isotype: IgG2a κ
• Purification Method: Affinity chromatography
• Product Type: Antibody