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IL-31 Polyclonal Antibody, Biotin, PeproTech®, Invitrogen™
Rabbit Polyclonal Antibody
$250.00 - $2175.00
Specifications
Antigen | IL-31 |
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Concentration | 0.1-1.0 mg/mL |
Applications | ELISA, Western Blot |
Classification | Polyclonal |
Conjugate | Biotin |
Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
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Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
500P249BT25
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Invitrogen™
500P249BT25UG |
25 μg |
Each for $250.00
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500P249BT50
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Invitrogen™
500P249BT50UG |
50 μg |
Each for $319.00
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50-271-8571
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Invitrogen™
500P249BT500UG |
500 μg |
Each for $2,175.00
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Description
AA Sequence of recombinant protein: SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human IL-31. Anti-Human IL-31-specific antibody was purified by affinity chromatography and then biotinylated. Sandwich ELISA: To detect hIL-31 by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.25-1.0 μg/mL of this antibody is required. This biotinylated polyclonal antibody, in conjunction with PeproTech Polyclonal Anti-Human IL-31 (500-P249) as a capture antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant hIL-31. Western Blot: To detect hIL-31 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant hIL-31 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions. 500-P249BT-1MG will be provided as 2 x 500 μg
Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.Specifications
IL-31 | |
ELISA, Western Blot | |
Biotin | |
Rabbit | |
Human | |
Q6EBC2 | |
386653 | |
E.coli-derived Recombinant Human IL-31. | |
Antigen affinity chromatography | |
Il31 |
0.1-1.0 mg/mL | |
Polyclonal | |
Lyophilized | |
RUO | |
PBS with no preservative | |
1700013B14Rik; IL31; IL-31; ILN; Interleukin; interleukin 31; interleukin-31 | |
Il31 | |
Primary | |
-20°C |
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