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  6. Invitrogen™ IL-33R (ST2) Monoclonal Antibody (RMST2-2), APC-eFluor™ 780, eBioscience™, Invitrogen™ 

Invitrogen™ IL-33R (ST2) Monoclonal Antibody (RMST2-2), APC-eFluor™ 780, eBioscience™, Invitrogen™

Catalog No. p-7192824
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47-933-580 25 μg
47-933-582 100 μg
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Catalog No. 47-933-580 Supplier Invitrogen™ Supplier No. 47933580
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Description

Rat Monoclonal Antibody

IL-33R, also known as ST2, is a receptor for IL-33. It is a member of the IL-1 receptor family of innate receptors. Its extracellular domain consists of 3 Ig-like domains that directly interact with its co-receptor IL-1RAcP, and the ligand alarmin, IL-33. IL-33 ligation results in the association of IL-33R complex with its adaptor proteins MyD88, IRAK1, IRAK4 and TRAF6, and activation of the NF-kB, and MAPK pathways. This, in turn, instigates the release of chemokines and cytokines such as IL-5, IL-6, IL-8, and IL-13. Two most common isoforms of IL-33R that result from alternative splicing are ST2L - the membrane bound form, and ST2S - the soluble form. The membrane bound form can be released from the cell surface by proteolytic cleavage. The soluble forms have been suggested to act as decoys dampening the IL-33 signaling. IL-33R is primarily expressed by mast cells, basophils, and eosinophils. In mouse, IL-33R expression has been shown on ILC2 and Th2 cells. IL-33R signaling has been implicated in the number of immune conditions, including allergies, arthritis, atherosclerosis and sepsis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IL-33R (ST2)
Applications Flow Cytometry
Classification Monoclonal
Clone RMST2-2
Concentration 0.2 mg/mL
Conjugate APC-eFluor 780
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene IL1RL1
Gene Accession No. P14719
Gene Alias DER4; Fit1; Fit-1; Fos-responsive gene 1 protein; growth stimulation-expressed; homolog of mouse growth stimulation-expressed; IL-1 R4; IL1RL1; IL-1RL1; IL33R; IL-33R; interleukin 1 receptor like 1; interleukin 1 receptor-like 1; interleukin 1 receptor-related protein; Interleukin1 receptor like 1; interleukin-1 receptor-like 1; Interleukin-33 receptor alpha chain; Ly84; lymphocyte antigen 84; Protein ST2; Protein T1; sIL 33R; soluble IL 33 Receptor; soluble IL 33R; St2; ST2L; St2-rs1; ST2V; Ste2; T1; T1/ST2
Gene Symbols IL1RL1
Host Species Rat
Purification Method Affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17082
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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Safety and Handling

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