Importin 7 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-156-3318	Bethyl Laboratories, Inc A302726AT	20 μL

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Importin-7 (IOP7) belongs to the Importin beta family and contains an importin N-terminal domain. It functions in nuclear protein import in association with importin-beta subunit KPNB1. It mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 and thenuclear import of H2A, H2B, H3 and H4 histones in vitro.Studies suggest itacts as a nuclear import receptor for the Glucocorticoid receptors. It also acts as a receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism.Reports indicatethat in HIV-1 infection,IOP7 binds and mediates the nuclear import of HIV-1 Rev.

Specifications

• Antigen: Importin 7
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Alias: FLJ14581, Imp7, MGC138673, RANBP7
• Gene Symbols: IPO7
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody

• Applications: Immunohistochemistry, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: O95373
• Gene ID (Entrez): 10527
• Immunogen: Between 50 and 100
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Gene: IPO7