Integrin beta 3/CD61 Antibody (Y2/51), DyLight 488, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP254418G

Catalog No. NBP254418G

Description

Integrin beta 3/CD61 Monoclonal specifically detects Integrin beta 3/CD61 in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen.

Specifications

• Antigen: Integrin beta 3/CD61
• Classification: Monoclonal
• Conjugate: DyLight 488
• Formulation: 50 mM sodium borate with 0.05% sodium azide
• Gene Symbols: ITGB3
• Immunogen: Phytohemagglutinin (PHA)-stimulated peripheral blood cells
• Quantity: 0.1 mL
• Primary or Secondary: Primary
• Test Specificity: Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain). It associates with the IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61).The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.
• Content And Storage: Store at 4°C in the dark.

• Applications: Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
• Clone: Y2/51
• Dilution: Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin
• Gene Alias: CD61, CD61 antigen, GP3Aplatelet glycoprotein IIIa, GPIIIaintegrin beta-3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), ITG B3, Platelet membrane glycoprotein IIIa
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Research Discipline: Angiogenesis, Cancer, Cell Biology, Cellular Markers, Cytoskeleton Markers, Extracellular Matrix, Immunology, Phospho Specific, Signal Transduction, Stem Cell Markers
• Gene ID (Entrez): 3690.0
• Target Species: Human
• Isotype: IgG1 κ