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Integrin beta 4/CD104 Antibody (UM-A9), Alexa Fluor™ 350, Novus Biologicals™
SDP

Catalog No. NP23407A30 Shop All R&D Systems Products
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NP23407A30 0.1 mL
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Catalog No. NP23407A30 Supplier Novus Biologicals Supplier No. NBP234507AF350
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Description

Mouse Monoclonal Antibody

Integrin beta 4/CD104 Monoclonal specifically detects Integrin beta 4/CD104 in Human samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence.

Specifications

Antigen Integrin beta 4/CD104
Applications Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen)
Classification Monoclonal
Clone UM-A9
Conjugate Alexa Fluor 350
Dilution Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Frozen
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias CD104, CD104 antigen, GP150, integrin beta-4, integrin beta-4 subunit, integrin, beta 4
Gene Symbols ITGB4
Host Species Mouse
Immunogen Human squamous cell carcinoma (UM-SCC1)
Purification Method Protein A or G purified
Quantity 0.1 mL
Research Discipline Adaptive Immunity, Immunology, Phospho Specific, Signal Transduction
Primary or Secondary Primary
Gene ID (Entrez) 3691.0
Test Specificity Recognizes a protein of 205kDa, which is identified as integrin beta-4 (ITGB4). Its epitope is localized in the extracellular domain of ITGB4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta-4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG2a κ
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