Integrin beta 7 Antibody (FIB27), FITC, Novus Biologicals™

Rabbit Monoclonal Antibody

Supplier:  Novus Biologicals NBP281087F

Catalog No. NB015756

Description

Integrin beta 7 Monoclonal specifically detects Integrin beta 7 in Human, Mouse samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence.

Specifications

• Antigen: Integrin beta 7
• Classification: Monoclonal
• Conjugate: FITC
• Formulation: PBS
• Gene Symbols: ITGB7
• Immunogen: FIB27 was prepared by immunizing rats with TK1 cells.
• Quantity: 0.1 mL
• Research Discipline: Signal Transduction
• Gene ID (Entrez): 3695
• Target Species: Human, Mouse
• Form: Purified

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence
• Clone: FIB27
• Dilution: Flow Cytometry, Immunocytochemistry/Immunofluorescence
• Gene Alias: Gut homing receptor beta subunit, integrin beta 7 subunit, integrin beta-7, integrin, beta 7
• Host Species: Rabbit
• Purification Method: Protein A purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: FIB27 binds specifically to both human and mouse Integrin beta 7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway). Integrin beta 7 is one subunit is a heterodimer which makes up an intergin molecule. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis.
• Content And Storage: Store at 4°C in the dark.
• Isotype: IgG κ