IRF3 Polyclonal Antibody, Bethyl Laboratories

Catalog No.	Quantity
50-155-7595	20 μL

Catalog No. 50-155-7595 Supplier Bethyl Laboratories, Inc Supplier No. A300426AT

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IRF-3 is encoded by the IRF-3 gene located on chromosome 19 in humans and belongs to the Interferon regulatory transcription factor (IRF) family. IRF-3 plays a critical role in the response of the immune system to viral infection. It binds to the Interferon stimulated response element (ISRE) of its downstream target genes such as Interferon alpha and beta to activate their transcription which eventually leads to immune modulatory actions of the type I Interferon (IFN) pathway. Following phosphorylation on Serine 396, IRF-3 has been shown to affiliate with CREB binding protein (CREBBP) and translocate to the nucleus which is critical for its ability to bind to DNA and act as a transcription factor. Additionally, phosphorylation associated nuclear translocation may also protect IRF-3 from degradation by the virus machinery.

Specifications

• Antigen: IRF3
• Applications: Immunohistochemistry, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene: IRF3
• Gene Accession No.: Q14653
• Gene Alias: IRF-3
• Gene Symbols: IRF3
• Host Species: Rabbit
• Immunogen: Between 100 and 150
• Purification Method: Antigen affinity chromatography
• Quantity: 20 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3661
• Target Species: Human
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG