IRGC Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-9205	Proteintech Group Inc 140901AP150UL	150 μL

Description

Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.

Specifications

• Antigen: IRGC
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q6AYF9, Q6NXR0, Q8C262
• Gene ID (Entrez): 210145, 308428, 56269
• Immunogen: IRGC Fusion Protein Ag5279
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: IRGC

• Concentration: 0.16 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: CINEMA, Iigp5, Interferon inducible GTPase 5, IRGC, IRGC1, R30953_1
• Gene Symbols: IRGC
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody