IRGC Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Catalog No.	Quantity
50-172-9205	150 μL

Catalog No. 50-172-9205 Supplier Proteintech Group Inc Supplier No. 140901AP150UL

Description

Rabbit Polyclonal Antibody

Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.

Specifications

• Antigen: IRGC
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.16 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: IRGC
• Gene Accession No.: Q6AYF9, Q6NXR0, Q8C262
• Gene Alias: CINEMA, Iigp5, Interferon inducible GTPase 5, IRGC, IRGC1, R30953_1
• Gene Symbols: IRGC
• Host Species: Rabbit
• Immunogen: IRGC Fusion Protein Ag5279
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 210145, 308428, 56269
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG