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Isocitrate Dehydrogenase 1/IDH1 Antibody (IDH1/1152), Alexa Fluor™ 594, Novus Biologicals™
SDP

Catalog No. NB007232 Shop All R&D Systems Products
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NB007232 0.1 mL
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Catalog No. NB007232 Supplier Novus Biologicals Supplier No. NBP247744AF594
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Description

Mouse Monoclonal Antibody

Isocitrate Dehydrogenase 1/IDH1 Monoclonal specifically detects Isocitrate Dehydrogenase 1/IDH1 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen Isocitrate Dehydrogenase 1/IDH1
Applications Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone IDH1/1152
Conjugate Alexa Fluor 594
Dilution Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias Cytosolic NADP-isocitrate dehydrogenase, EC 1.1.1.42, IDCD, IDH, IDP, IDPC, isocitrate dehydrogenase [NADP] cytoplasmic, isocitrate dehydrogenase 1 (NADP+), soluble, NADP(+)-specific ICDH, NADP-dependent isocitrate dehydrogenase, cytosolic, NADP-dependent isocitrate dehydrogenase, peroxisomal, Oxalosuccinate decarboxylase, PICD
Gene Symbols IDH1
Host Species Mouse
Immunogen Recombinant fragment of human Isocitrate Dehydrogenase 1/IDH1 protein (around aa 281-414) (exact sequence is proprietary) (Uniprot: O75874 )
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Stem Cell Markers
Primary or Secondary Primary
Test Specificity It recognizes a 45kDa protein, which is identified as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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