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Isocitrate Dehydrogenase 1/IDH1 Antibody (IDH1/1152) - Azide and BSA Free, Novus Biologicals™
Mouse Monoclonal Antibody
Supplier: Novus Biologicals NBP2477440.2MG
Description
Isocitrate Dehydrogenase 1/IDH1 Monoclonal antibody specifically detects Antigen in Human samples. It is validated for Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blotting.Specifications
Isocitrate Dehydrogenase 1/IDH1 | |
Monoclonal | |
1.0 mg/mL | |
Western Blot : 0.5 - 1.0 ug/ml, Flow Cytometry : 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin : 0.5 - 1.0 ug/ml, Immunofluorescence : 0.5 - 1.0 ug/ml, CyTOF-ready | |
Cytosolic NADP-isocitrate dehydrogenase, EC 1.1.1.42, IDCD, IDH, IDP, IDPC, isocitrate dehydrogenase [NADP] cytoplasmic, isocitrate dehydrogenase 1 (NADP+), soluble, NADP(+)-specific ICDH, NADP-dependent isocitrate dehydrogenase, cytosolic, NADP-dependent isocitrate dehydrogenase, peroxisomal, Oxalosuccinate decarboxylase, PICD | |
Mouse | |
46 kDa | |
0.2 mg | |
Stem Cell Markers | |
3417 | |
Human | |
Purified |
Western Blot, Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence, CyTOF | |
IDH1/1152 | |
Unconjugated | |
PBS with No Preservative | |
IDH1 | |
Recombinant fragment (119 Amino acid residues around aa 280-420) of human IDH1 protein | |
Protein A or G purified | |
RUO | |
Primary | |
It recognizes a 45kDa protein, which is identified as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway. | |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | |
IgG1 κ |
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