Tocris™ IWP L6

Potent PORCN inhibitor

Manufacturer: Tocris™ 4992/50

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Catalog No. 49-925-0R

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For Research Use Only


    Inhibitors IWP L6
    Purity >98
    Molecular Weight 472.58
    Quantity 50mg
    Product Type IWP L6

    Potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (EC50 = 0.5nM). Shown to inhibit Wnt-dependent processes such as tailfin regeneration and posterior axis formation in zebrafish; also reduces branching morphogenesis in cultured mouse embryonic kidneys.

    • Chemical Name: N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide
    • Formula: C25H20N4O2S2
    • CAS Number: 1427782-89-5
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >98

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