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JARID1B Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories

Catalog No. 501559779
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50-155-9779 100 μL
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Catalog No. 50-155-9779 Supplier Bethyl Laboratories, Inc Supplier No. A301813A
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Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

KDM5B is a histone demethylase that demethylates ′Lys-4′ of histone H3, thereby playing a central role in histone code. It does not demethylate histone H3 ′Lys-9′ or H3 ′Lys-27′. KDM5B demethylates trimethylated, dimethylated and monomethylated H3 ′Lys-4′. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.

Specifications

Antigen JARID1B
Applications Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene KDM5B
Gene Accession No. Q80Y84, Q9UGL1
Gene Alias RBBP2H1A, PLU1, PLU-1, CT31, lysine K-specific demethylase 5B, JARID1B, PUT1
Gene Symbols Kdm5b
Host Species Rabbit
Immunogen Between 1494 and 1544
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10765, 75605
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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