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Tocris™ JIB 04

Pan Jumonji inhibitor; active in vivo

Manufacturer:  Tocris™ 4972/50

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Catalog No. 49-725-0R


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For Research Use Only


Specifications

Description

Pan Jumonji histone demethylase inhibitor (IC50 values are 230, 340, 435, 445, 855 and 1100nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). Exhibits negligible activity at PHD2 and TET1. Selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. Prolongs survival in a mouse model of breast cancer.
  • Chemical Name: 5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine
  • Formula: C17H13ClN4
  • CAS Number: 199596-05-9
  • Solubility: Soluble to 100mM in DMSO and to 50mM in 1eq. HCl
  • Purity: >99
Description & Specifications

Specifications

JIB 04
>99
50mg
JIB 04
308.76
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