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JMJD1C Polyclonal Antibody, Bethyl Laboratories

Catalog No. p-7140496
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50-155-8704 20 μL
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Catalog No. 50-155-8704 Supplier Bethyl Laboratories, Inc Supplier No. A300884AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico, and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in the nuclear hormone receptor-based transcriptional regulation. JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells as well as pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contain bHLH-, AP-1-, and POU5F1-binding sites, and as preferential expression of POU5F1 has been reported in ES cells, pancreatic islet, and diffuse-type gastric cancer, it has been suggested that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in ES cells and diffuse-type gastric cancer. At least three isoforms of JMJD1C are known to exist.

Specifications

Antigen JMJD1C
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene JMJD1C
Gene Accession No. Q15652
Gene Alias RP11-10C13.2, TRIP8; TR-interacting protein 8; TRIP-8; jumonji domain-containing protein 1C; probable JmjC domain-containing histone demethylation protein 2C; thyroid hormone receptor interactor 8; thyroid receptor interacting protein 8; thyroid receptor-interacting protein 8
Gene Symbols JMJD1C
Host Species Rabbit
Immunogen Between 150 and 200
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 221037
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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