Invitrogen™ KCNE1L Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA568274

Catalog No. PIPA568274

Description

Predicted to react with Mouse and Rat samples.

Kcne1 is a member of Voltage-gated potassium (Kv) channels that represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. The diverse functions of Kv channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. The Kcne1 gene encodes a membrane protein which has sequence similarity to the KCNE1 gene product, a member of the potassium channel, voltage-gated, isk-related subfamily. Kcne1, an intronless gene is deleted in AMME contiguous gene syndrome and may be involved in the cardiac and neurologic abnormalities found in the AMME contiguous gene syndrome. Functionally, Kcne1 is a potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Kcne1 also functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. Diseases associated with KCNE1 include Jervell And Lange-Nielsen Syndrome 2 and Long Qt Syndrome 5.

Specifications

• Antigen: KCNE1L
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KCNE5
• Gene Alias: 1500015C14Rik; AMME syndrome candidate gene 2 protein; AMMECR2; AMMECR2 protein; cardiac voltage-gated potassium channel accessory subunit 5; KCNE1L; KCNE1-like; Kcne5; Mink; MinK-like protein; potassium channel subunit beta MiRP4; potassium channel, voltage gated subfamily E regulatory beta subunit 5; potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 5; potassium voltage-gated channel subfamily E member 1-like protein; Potassium voltage-gated channel subfamily E regulatory beta subunit 5; potassium voltage-gated channel subfamily E regulatory subunit 5; potassium voltage-gated channel, Isk-related family, member 1-like; potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene; voltage-gated potassium channel accessory subunit 5
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23630, 681190
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q9UJ90
• Gene Symbols: KCNE5
• Immunogen: Synthesized peptide derived from human KCNE1L.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG