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Ki-67 Recombinant Rat Monoclonal Antibody (SolA15), Invitrogen™

Rat Recombinant Monoclonal Antibody

$211.00 - $437.00

Specifications

Antigen Ki-67
Clone SolA15
Concentration 1.0 mg/mL
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Recombinant Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
74-000-8T
Encompass_Preferred
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Invitrogen™
740008T
100 μL
Each for $437.00
Only null left
Edge
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74-000-8T20UG
Encompass_Preferred
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Invitrogen™
740008T20UG
20 μL
Each for $211.00
Only null left
Add to Cart
 
Description

Description

Recombinant Rat monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus. Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic tissues, the prognostic value is comparable to the tritiated thymidine-labelling index. The correlation between low Ki-67 index and histologically low-grade tumors is strong. Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation.
Specifications

Specifications

Ki-67
1.0 mg/mL
Recombinant Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.4
antigen identified by monoclonal antibody Ki 67; antigen identified by monoclonal antibody Ki-67; Antigen identified by monoclonal antibody Ki-67 homolog; Antigen KI-67; Antigen KI-67 homolog; antigen KI-67; proliferation marker protein Ki-67; antigen KI-67-like; cb31; D630048A14Rik; I79_022666; Ki67; Ki-67; KIA; LOW QUALITY PROTEIN: proliferation marker protein Ki-67; marker of proliferation Ki-67; MIB-; MIB-1; Mki67; PPP1R105; Proliferation marker protein Ki-67; proliferation-related Ki-67 antigen; protein phosphatase 1, regulatory subunit 105; RP11-380J17.2; sb:cb31; si:ch211-250b22.7; unnamed protein product; wu:fa11g09; wu:fb57a07; wu:fi14e05
Mki67
Primary
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
SolA15
Flow Cytometry, Immunohistochemistry (Paraffin), Immunocytochemistry
Unconjugated
Rat
Human, Mouse
E9PVX6, P46013
17345, 4288
IgG2a κ
Affinity Chromatography
Mki67
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