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KIR3DL1 Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501728661 Shop All Proteintech Group Inc Products
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50-172-8661 150 μL
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Catalog No. 50-172-8661 Supplier Proteintech Group Inc Supplier No. 133351AP150UL
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Description

Rabbit Polyclonal Antibody

This antibody is raised against 22-344 amino acids of human KIR3DL1 and recognizes both KIR3DL1 (49 kDa) and KIR3DS1 (43 kDa).

KIR3DL1 are Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Specifications

Antigen KIR3DL1
Applications Flow Cytometry, Western Blot
Classification Polyclonal
Concentration 0.23 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene KIR3DL1
Gene Accession No. P43629
Gene Alias CD158E, CD158E1, KIR, KIR3DL1, MHC class I NK cell receptor, NKAT 3, NKAT3, NKB1, NKB1B, p70 NK receptor CL 2/CL 11
Gene Symbols KIR3DL1
Host Species Rabbit
Immunogen KIR3DL1 Fusion Protein Ag4152
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3811
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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