KLHDC3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-9081	Proteintech Group Inc 139051AP150UL	150 μL

Description

This antibody specifically reacts with the 55 kDa KLHDC3 protein.

The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. The Kelch domain-containing protein 3 (KLHDC3), also designated PEAS, contains 5 Kelch repeats and may be involved in meiotic recombination process. The gene encoding KLHDC3 maps to chromosome 6, which contains around 1, 200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda, Parkinson′s disease, Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. KLHDC3 protein is mainly expressed in cytoplasm, also found in meiotic chromatin.

Specifications

• Antigen: KLHDC3
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q6AYI2, Q8VEM9, Q9BQ90
• Gene ID (Entrez): 116138, 363192, 71765
• Immunogen: KLHDC3 Fusion Protein Ag4879
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: KLHDC3

• Concentration: 0.52 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: hPEAS, kelch domain containing 3, KLHDC3, PEAS, Protein Peas, RP1 20C7.3
• Gene Symbols: Klhdc3
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody