Invitrogen™ Klotho Monoclonal Antibody (C3), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA543726

Catalog No. PIMA543726

Description

KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.

Specifications

• Antigen: Klotho
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene Accession No.: Q9UEF7
• Gene Symbols: KL
• Immunogen: Phe765-Ser981 (Accession Q9UEF7), with Two N-terminal Tags, His-tag and SUMO-tag.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: Western Blot
• Clone: C3
• Conjugate: Unconjugated
• Gene: KL
• Gene Alias: alpha-kl; HFTC3; Kl; Klotho; Klotho peptide; secreted form of Klotho protein
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 9365
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid