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  7. KML 29, Tocris Bioscience™

KML 29, Tocris Bioscience™

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Quantity:
10mg
50mg
This item is not returnable. View return policy
1380424-42-9
C24H21F6NO7
549.422
SXHQLPHDBLTFPM-UHFFFAOYSA-N
kml29,kml-29,kml 29,1,1,1,3,3,3-hexafluoropropan-2-yl 4-bis 1,3-benzodioxol-5-yl-hydroxymethyl piperidine-1-carboxylate,1,1,1,3,3,3-hexafluoropropan-2-yl 4-bis 2h-1,3-benzodioxol-5-yl hydroxy methyl piperidine-1-carboxylate,4-bis 1,3-benzodioxol-5-yl hydroxymethyl-1-piperidinecarboxylic acid 2,2,2-trifluoro-1-trifluoromethyl ethyl ester
71656212
1,1,1,3,3,3-hexafluoropropan-2-yl 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC(C(F)(F)F)C(F)(F)F
This item is not returnable. View return policy
1380424-42-9
C24H21F6NO7
549.422
SXHQLPHDBLTFPM-UHFFFAOYSA-N
kml29,kml-29,kml 29,1,1,1,3,3,3-hexafluoropropan-2-yl 4-bis 1,3-benzodioxol-5-yl-hydroxymethyl piperidine-1-carboxylate,1,1,1,3,3,3-hexafluoropropan-2-yl 4-bis 2h-1,3-benzodioxol-5-yl hydroxy methyl piperidine-1-carboxylate,4-bis 1,3-benzodioxol-5-yl hydroxymethyl-1-piperidinecarboxylic acid 2,2,2-trifluoro-1-trifluoromethyl ethyl ester
71656212
1,1,1,3,3,3-hexafluoropropan-2-yl 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC(C(F)(F)F)C(F)(F)F

Description

Highly potent and selective MAGL inhibitor

Highly selective and potent monoacylglycerol lipase (MAGL) inhibitor. Exhibits potent inhibition of human, mouse and rat MAGL (IC50 values are 5.9, 15 and 43 nM, respectively). Exhibits no detectable inhibition of FAAH (IC50 > 50000 nM). Potently and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50 = 2.5 nM and >50 μM for 2-AG and AEA respectively).
Quantity 50mg
Formula Weight 549.42
Chemical Name or Material KML 29

Safety and Handling

Recommended Storage : Store at -20°C