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Thermo Scientific™ Lab Vision™ Ku (p70/p80) Ab-3, Mouse Monoclonal Antibody

Recommended for multiple molecular biology techniques, Thermo Scientific™ Ku (p70/p80) Ab-3, Mouse Monoclonal Antibody provides accurate, reproducible results.

Specifications

Antigen Ku (p70/p80) Ab-3
Clone 162
Applications Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Monoclonal
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Formulation Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Formulation Quantity Price Quantity & Availability  
MS286P1
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Thermo Scientific™
MS286P1
Purified Ab with BSA and Azide 500μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
MS286R1
View Documents
Thermo Scientific™
MS286R1
Ready-to-use for IHC (UVLP) 1mL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
Description

Description

Recommended for multiple molecular biology techniques, Thermo Scientific™ Ku (p70/p80) Ab-3, Mouse Monoclonal Antibody provides accurate, reproducible results.

The Ku autoantigen is a heterodimer of 70kDa (p70) and ~80kDa (p80) proteins. The p70/p80 dimer is important for function of a 460kDa DNA-dependent protein kinase that phosphorylates certain transcription factors, including Sp1, Oct-1, p53, and SV40 large T antigen in vitro. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.

Host Species: Mouse

Clone: 162

Isotype: IgG2a

Species Reactivity: Human, Monkey, Xenopus. Mouse and Rat (Immunoprecipitation only). Does not react with cow and rabbit.

Epitope: A conformational epitope of p70/p80 dimer, which is destroyed during Western Blotting

Immunogen: Human B-cell nuclei from plasmacytoid 2p68 cells

Molecular Weight: 70kDa and 80kDa

Positive Control: Tonsil

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting (Not suitable)
  • Immunofluorescence
  • Affinity Purification
  • Flow Cytometry
  • Gel Supershift

General References:

1. Wang J, et. al. Molecular Biology Reports, 1993, 18(1):15-28.

2. Reeves WH, et. al. Journal of Experimental Medicine, 1985, 161(1):18-39.

Specifications

Specifications

Ku (p70/p80) Ab-3
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin)
Unconjugated
RUO
Primary
IgG2a
162
Monoclonal
Murine
DNA Repair
Human B cell nuclei from plasmacytoid 2p68 cells
SDS
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