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Ku70/XRCC6 Mouse, Clone: KU729, Novus Biologicals™
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Catalog No. NBP234247B Shop All R&D Systems Products
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Catalog No. Quantity
NBP234247B 0.2 mg
NBP234247F 0.02 mg
NBP234247A 0.1 mg
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Catalog No. NBP234247B Supplier Novus Biologicals Supplier No. NBP2342470.2MG

Description

Mouse Monoclonal Antibody

Ku70/XRCC6 Monoclonal antibody specifically detects Antigen in Chicken (Negative), Human, Mouse (Negative), Primate, Rat (Negative) samples. It is validated for Immunocytochemistry/Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation.

Specifications

Antigen Ku70/XRCC6
Applications Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Classification Monoclonal
Clone KU729
Conjugate Unconjugated
Dilution Immunocytochemistry/Immunofluorescence 0.5-1.0ug/ml, Immunoprecipitation 0.5-1ug/500ug protein lysate, Immunohistochemistry-Paraffin 0.5-1ug/ml, Immunohistochemistry-Frozen 0.5-1ug/ml
Formulation PBS with 0.05% BSA. with 0.05% Sodium Azide
Gene Accession No. P12956
Gene Alias 5'-deoxyribose-5-phosphate lyase Ku70, 5'-dRP lyase Ku70, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, CTC box binding factor 75 kDa subunit, CTC box-binding factor 75 kDa subunit, CTC75, CTCBF, D22S731, EC 3.6.4.-, EC 4.2.99.-, G22P1Ku70, Ku autoantigen p70 subunit, Ku autoantigen, 70kDa, KU70, ML8,70 kDa subunit, Thyroid-lupus autoantigen, thyroid-lupus autoantigen p70, TLAAD22S671, X-ray repair complementing defective repair in Chinese hamster cells 6DNA repair protein XRCC6, X-ray repair cross-complementing protein 6
Gene Symbols XRCC6
Host Species Mouse
Immunogen Nuclear extract of human HL-60 cells
Molecular Weight of Antigen 75 kDa
Purification Method Protein A purified
Quantity 0.2 mg
Regulatory Status RUO
Research Discipline Breast Cancer, Cancer, DNA Double Strand Break Repair, DNA Repair, Non homologous end joining
Primary or Secondary Primary
Gene ID (Entrez) 2547
Test Specificity Recognizes a dimer of two proteins of 70kDa and ∼80kDa, identified as two subunits of Ku. This MAb recognizes a conformational epitope of p70/p80 dimer, which is destroyed during Western blotting. The p70/p80 dimer is important for function of a 460kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
Target Species Human, Primate, Chicken (Negative), Mouse (Negative), Rat (Negative)
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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