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  8. L-655,708, Tocris Bioscience™ 

L-655,708, Tocris Bioscience™

Catalog Number 132710
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
130477-52-0
C18H19N3O4
341.367
YKYOQIXTECBVBB-AWEZNQCLSA-N
chembl52030, ethyl s-11,12,13,13a-tetrahydro-7-methoxy-9-oxo-9h-imidazo 1,5-a pyrrolo 2,1-c 1,4 benzodiazepine-1-carboxylate, l hplc , powder, s-9-methoxy-7-oxo-3b,4,5,6-tetrahydro-7h-2,6a,11b-triaza-benzo g cyclopenta e azulene-3-carboxylic acid ethyl ester, 11,12,13,13a-tetrahydro-7-methoxy-9-oxo-9h-imidazo 1,5-a pyrrolo 2,1-c 1,4 benzodiazepine-1-carboxylic acid, ethyl ester, 9-methoxy-7-oxo-3b,4,5,6-tetrahydro-7h-2,6a,11b-triaza-benzo g cyclopenta e azulene-3-carboxylic acid ethyl ester msd, ethyl 7s-15-methoxy-12-oxo-2,4,11-triazatetracyclo 11.4.0.0 2 ,?.0?, 1 1 heptadeca-1 17 ,3,5,13,15-pentaene-5-carboxylate, ethyl s-11,12,13,13a-tetrahydro-7-methoxy-9-oxo-9h-imidazo 1,5-a pyrro-lo 2,1-c 1,4-benzodiazepine-1-carboxylate
5311203
CCOC(=O)C1=C2C3CCCN3C(=O)C4=C(N2C=N1)C=CC(=C4)OC
This item is not returnable. View return policy
130477-52-0
C18H19N3O4
341.367
YKYOQIXTECBVBB-AWEZNQCLSA-N
chembl52030, ethyl s-11,12,13,13a-tetrahydro-7-methoxy-9-oxo-9h-imidazo 1,5-a pyrrolo 2,1-c 1,4 benzodiazepine-1-carboxylate, l hplc , powder, s-9-methoxy-7-oxo-3b,4,5,6-tetrahydro-7h-2,6a,11b-triaza-benzo g cyclopenta e azulene-3-carboxylic acid ethyl ester, 11,12,13,13a-tetrahydro-7-methoxy-9-oxo-9h-imidazo 1,5-a pyrrolo 2,1-c 1,4 benzodiazepine-1-carboxylic acid, ethyl ester, 9-methoxy-7-oxo-3b,4,5,6-tetrahydro-7h-2,6a,11b-triaza-benzo g cyclopenta e azulene-3-carboxylic acid ethyl ester msd, ethyl 7s-15-methoxy-12-oxo-2,4,11-triazatetracyclo 11.4.0.0 2 ,?.0?, 1 1 heptadeca-1 17 ,3,5,13,15-pentaene-5-carboxylate, ethyl s-11,12,13,13a-tetrahydro-7-methoxy-9-oxo-9h-imidazo 1,5-a pyrro-lo 2,1-c 1,4-benzodiazepine-1-carboxylate
5311203
CCOC(=O)C1=C2C3CCCN3C(=O)C4=C(N2C=N1)C=CC(=C4)OC

Description

Benzodiazepine inverse agonist; selective for α5-containing GABAA receptors

Potent, selective inverse agonist for the benzodiazepine site of GABAA receptors containing the α5 subunit (Ki = 0.45 nM). Displays 50-100-fold selectivity over GABAA receptors containing α1, α2, α3 or α6 subunits in combination with β3 and γ2. Enhances LTP in a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.
Quantity 10 mg
Formula Weight 341.37
Percent Purity >99%
Chemical Name or Material L-655, 708

Safety and Handling

Recommended Storage Desiccate at +4°C
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