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Tocris Bioscience™ L-685,458
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Catalog No. 26271
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26-271 1 mg
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Catalog No. 26-271 Supplier Tocris Bioscience™ Supplier No. 2627/1
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Description

Potent and selective γ-secretase inhibitor

Potent and selective γ-secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of Aβ40 and Aβ42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro.

Chemical Identifiers

CAS 292632-98-5
Molecular Formula C39H52N4O6

Specifications

Quantity 1 mg
Formula Weight 672.85
Purity >97%
Molecular Weight (g/mol) 672.867
Chemical Name or Material L-685, 458

Safety and Handling

Recommended Storage Store at -20°C
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