L-Selectin/CD62L Antibody (FMC46), DyLight 488, Novus Biologicals™

Catalog No.	Quantity
NB10065388G	0.1 mL

Catalog No. NB10065388G Supplier Novus Biologicals Supplier No. NB10065388G

Description

Mouse Monoclonal Antibody

L-Selectin/CD62L Monoclonal specifically detects L-Selectin/CD62L in Human, Bovine, Canine, Primate samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen.

Specifications

• Antigen: L-Selectin/CD62L
• Applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Frozen)
• Classification: Monoclonal
• Clone: FMC46
• Conjugate: DyLight 488
• Dilution: Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen
• Gene Accession No.: P14151
• Gene Alias: CD62L, CD62L antigen, gp90-MEL, hLHRc, LAM-1, LAM1LECAM1, Leu-8, LEU8, Leukocyte adhesion molecule 1, Leukocyte surface antigen Leu-8, Leukocyte-endothelial cell adhesion molecule 1, LNHRTQ1, LSEL, L-selectin, Lyam-1, LYAM1CD62 antigen-like family member L, Lymph node homing receptor, lymphocyte adhesion molecule 1, pln homing receptor, PLNHR, selectin L
• Gene Symbols: SELL
• Host Species: Mouse
• Immunogen: PHA stimulated lymphoblasts.
• Purification Method: Protein G purified
• Quantity: 0.1 mL
• Regulatory Status: RUO
• Research Discipline: Adaptive Immunity, B Cell Development and Differentiation Markers, Cardiovascular Biology, Glycobiology, Immunology, Lipid and Metabolism, Myeloid derived Suppressor Cell, Signal Transduction, Stem Cells
• Primary or Secondary: Primary
• Gene ID (Entrez): 6402
• Test Specificity: NB100-65388 recognizes human CD62L, also known a L-selectin, a 74-95kDa member of the selectin family of adhesion receptors, which acts as a ligand for both CD62-P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes. CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naive lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains. The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation.
• Target Species: Human, Bovine, Canine, Primate
• Content And Storage: Store at 4C in the dark.
• Form: Purified
• Isotype: IgG2b

For Research Use Only