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MGMT (O-methylguanine-DNA methyltransferase) Ab-1 Mouse Monoclonal Antibody, Epredia™
Epredia™ MGMT (O-methylguanine-DNA methyltransferase) Ab-1, Mouse Monoclonal Antibody provides accurate, reproducible results.
$736.00 - $1365.00
Specifications
| Antigen | MGMT (O-methylguanine-DNA methyltransferase) Ab-1 |
|---|---|
| Clone | MT 3.1 |
| Applications | Immunohistochemistry (Paraffin), Western Blot |
| Classification | Monoclonal |
| Host Species | Mouse |
| Catalog Number | Mfr. No. | Form | Conjugate | Quantity | Price | Quantity & Availability | |||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Form | Conjugate | Quantity | Price | Quantity & Availability | |||
|
MS470B1
|
Epredia
MS470B1 |
Concentrated | Biotin | 500 μL |
Each for $799.00
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MS470B
|
Epredia
MS470B |
Concentrated | Biotin | 1 mL |
Each for $1,276.00
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MS470P1
|
Epredia
MS470P1 |
Concentrated | Unconjugated | 500 μL |
Each for $736.00
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MS470P
|
Epredia
MS470P |
Concentrated | Unconjugated | 1 mL |
Each for $1,365.00
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MS470B0
|
Epredia
MS470B0 |
Concentrated | Biotin | 100 μL | N/A | N/A | N/A | ||
|
MS470P0
|
Epredia
MS470P0 |
Concentrated | Unconjugated | 100 μL | N/A | N/A | N/A | ||
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MS470P1ABX
|
Epredia
MS470P1ABX |
Concentrated | Unconjugated | 100 μL | N/A | N/A | N/A | ||
|
MS470PABX
|
Epredia
MS470PABX |
Concentrated | Unconjugated | 200 μL | N/A | N/A | N/A | ||
Description
Cancer chemotherapeutic alkylating agents (e.g. BCNU,) act by inducing formation of lethal cross-links at the O-alkylguanine position in DNA. MGMT transfers alkyl adducts from the O-position of guanine in DNA (prior to cross-link formation) to a cysteine residue in its own sequence, thereby restoring DNA to its intact state. This transfer inactivates the MGMT enzyme and is irreversible; hence the level of MGMT in a cell is directly proportional to the level of DNA-damage it can tolerate. In normal tissues, MGMT acts as a suppressor of mutation and carcinogenesis. Tumors with high levels of MGMT are likely be drug-resistant.Host Species: Mouse
Clone: MT 3.1
Isotype: IgG1
Species Reactivity: Human. Also reacts weakly with Mouse, Rat and Hamster. Others not known.
Epitope: aa 8-221
Immunogen: Purified recombinant human MGMT protein
Molecular Weight: 25kDa
Positive Control: Raji cells, Colon CA
Cellular Localization: Nuclear and cytoplasmic
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting
- Flow Cytometry
Note:
USA: RUO; Int'l: RUO
Specifications
| MGMT (O-methylguanine-DNA methyltransferase) Ab-1 | |
| Immunohistochemistry (Paraffin), Western Blot | |
| Mouse | |
| Enzyme | |
| Purified recombinant human MGMT protein | |
| Primary |
| MT 3.1 | |
| Monoclonal | |
| RUO | |
| Hamster, Human, Mouse, Rat | |
| IgG1 |
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