Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

LAG-3 (CD223) Mouse anti-Human, APC-R700, Clone: T47-530, BD

Mouse Monoclonal Antibody

$155.00 - $325.00

Specifications

Antigen LAG-3 (CD223)
Clone T47-530
Immunogen Human LAG-3 Recombinant Protein
Host Species Murine
Isotype Mouse IgG1, κ
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB565775 View Documents BD Biosciences
565775
25 Tests Each for $155.00
Add to cart
 
BDB565774 View Documents BD Biosciences
565774
100 Tests Each for $325.00
Add to cart
 
Description

Description

The T47-530 specifically recognizes the Lymphocyte Activation Gene 3 (LAG-3) protein which is also known as, Protein FDC, or CD223. LAG-3 is a ñ70 kDa type I transmembrane glycoprotein that belongs to the Ig superfamily and exhibits homology to CD4. LAG-3 is expressed on NK cells, regulatory T cells, and activated conventional T cells with higher expression found on CD8+ T cells compared with CD4+ T cells. LAG-3 is an activation induced cell surface molecule that like CD4, binds MHC class II molecules, but with much higher affinity. This may enable LAG-3 to act as a negative competitor of CD4 for MHC class II ligand binding. LAG-3 may associate with the TCR-CD3 complex to downregulate TCR signal transduction and T cell clonal expansion. In contrast, LAG-3-induced signaling may promote dendritic cell activation.

This antibody was conjugated to BD Horizon APC-R700, which has been developed exclusively by BD Biosciences as a better alternative to Alexa Fluor™ 700. APC-R700 excites and emits at similar wavelengths to Alexa Fluor™ 700 yet exhibits significantly improved brightness. This dye can be excited by the red laser and detected with the same filter set as Alexa Fluor™ (eg, 730/45nm filter). APC-R700 is a tandem fluorochrome that combines APC with R700, a proprietary organic dye. This dye has been developed exclusively by BD Biosciences as a brighter alternative to Alexa Fluor™ 700. Due to similar excitation and emission properties, APC-R700 and Alexa Fluor™ 700 cannot be used simultaneously.
Specifications

Specifications

LAG-3 (CD223)
Human LAG-3 Recombinant Protein
Mouse IgG1, κ
Affinity Purified
Monoclonal
LAG3, CD223, FDC, Lymphocyte activation gene 3 protein, Protein FDC
RUO
T47-530
Murine
APC-R700
Aqueous buffered solution containing BSA, protein stabilizer, glycerol and ≤0.09% sodium azide.
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit