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Lamin A, mature Monoclonal Antibody (4A4), Active Motif™
Mouse Monoclonal Antibody
$156.65 - $620.58
Specifications
| Antigen | Lamin A, mature |
|---|---|
| Clone | 4A4 |
| Concentration | 1 mg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-199-3004
|
Active Motif
39962 |
10 μg |
Each for $156.65
|
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|
50-199-3003
|
Active Motif
39961 |
100 μg |
Each for $620.58
|
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Description
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.Specifications
| Lamin A, mature | |
| 1 mg/mL | |
| Monoclonal | |
| Liquid | |
| RUO | |
| 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8 | |
| 70 kDa lamin; BOS_2775; CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A; lamin A/C; lamin A/C-like 1; lamin C; lamin C2; Lamin-A/C; LDP1; LFP; LGMD1B; Lmn1; LMNA; LMNC; LMNL1; OTTHUMP00000015843; OTTHUMP00000015846; OTTHUMP00000015847; Prelamin-A/C; PRO1; Renal carcinoma antigen NY-REN-32 | |
| LMNA | |
| IgG1 | |
| Protein G | |
| Antibody |
| 4A4 | |
| Western Blot | |
| Unconjugated | |
| Mouse | |
| Human | |
| P02545 | |
| 4000 | |
| This Lamin A, mature antibody was raised against a peptide within the C-terminus of mature human Lamin A. | |
| Primary | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| LMNA |
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