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  5. Tocris Bioscience™ LDN 193189 dihydrochloride

Tocris Bioscience™ LDN 193189 dihydrochloride
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Catalog No. 605350
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60-535-0 50 mg
60-531-0 10 mg
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Catalog No. 60-535-0 Supplier Tocris Bioscience™ Supplier No. 6053/50
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Description

Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs

LDN 193189 dihydrochloride is a potent and selective ALK2 and ALK3 inhibitor (IC50 values are 5 and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation. Exhibits >200-fold selectivity for BMP signaling over TGF-β signaling. Also exhibits selectivity over AMPK, PDGFR and MAPK signaling. Promotes neural induction of hPSCs in combination with SB 431542 (Cat.No. 1614). Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with SB 431542 (Cat.No. 1614), SU 5402 (Cat.No.3300), CHIR 99021 (Cat.No. 4423) and DAPT (Cat.No. 2634).

LDN 193189 synthesized to Ancillary Material Grade also available.

For more information about how LDN 193189 dihydrochloride may be used, see our protocols: Generation of β cells from hPSCs, Generating Midbrain Dopaminergic Neurons from hPSCs, Accelerated Induction of Cortical Neurons from hiPSCs .

Specifications

Chemical Name or Material 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
CAS 1435934-00-1
Synonym 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Quantity 50 mg
Solubility Soluble to 50mM in water and to 20mM in DMSO
Target BMP and Other Activin Receptor Inhibitors
Molecular Formula C25H22N60.2 HCl
Formula Weight 479.4
Physical Form Solid
Color Orange
Product Type Bioactive Small Molecule
Purity 98%
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For Research Use Only.

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