Invitrogen™ LFNG Monoclonal Antibody (4F8)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA519262

Catalog No. PIMA519262

Description

Peptide Sequence: MTPGRCCLAA DIQVETFIFT DGEDEALARH TGNVVITNCS AAHSRQALSC KMAVEYDRFI ESGRKWFCHV DDDNYVNLRA LLRLLASYPH TRDVYVGKPS LDRPIQAMER VSENKVRPVH FWFATGGAGF CISRGLALKM SPWASGGHFM NTAERIRLPD DCTIGYIVEA LLGVPLIRSG LFHSHLENLQ QVPTSELHEQ VTLSYGMFEN KRNAVHVKGP FSVEADPSRF RSIHCHLYPD TPWCPRTAIF.

LFNG belongs to evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This protein is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150).

Specifications

• Antigen: LFNG
• Classification: Monoclonal
• Concentration: 0.2-1.0 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q8NES3
• Gene Symbols: LFNG
• Immunogen: LFNG (AAH14851, 1 a.a. ~ 250 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b κ

• Applications: ELISA, Immunoprecipitation
• Clone: 4F8
• Conjugate: Unconjugated
• Gene: LFNG
• Gene Alias: AW061165; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; LFNG; LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; lunatic fringe; lunatic fringe gene homolog; MGC128664 protein; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; SCDO3
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3955
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid