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Invitrogen™ LFNG Monoclonal Antibody (4F8)
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Catalog No. PIMA519262
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100 μg
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Catalog No. Quantity
PIMA519262 100 μg
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Catalog No. PIMA519262 Supplier Invitrogen™ Supplier No. MA519262
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Description

Mouse Monoclonal Antibody

Peptide Sequence: MTPGRCCLAA DIQVETFIFT DGEDEALARH TGNVVITNCS AAHSRQALSC KMAVEYDRFI ESGRKWFCHV DDDNYVNLRA LLRLLASYPH TRDVYVGKPS LDRPIQAMER VSENKVRPVH FWFATGGAGF CISRGLALKM SPWASGGHFM NTAERIRLPD DCTIGYIVEA LLGVPLIRSG LFHSHLENLQ QVPTSELHEQ VTLSYGMFEN KRNAVHVKGP FSVEADPSRF RSIHCHLYPD TPWCPRTAIF.

LFNG belongs to evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This protein is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150).
TRUSTED_SUSTAINABILITY

Specifications

Antigen LFNG
Applications ELISA, Immunoprecipitation
Classification Monoclonal
Clone 4F8
Concentration 0.2-1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene LFNG
Gene Accession No. Q8NES3
Gene Alias AW061165; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; LFNG; LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; lunatic fringe; lunatic fringe gene homolog; MGC128664 protein; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; SCDO3
Gene Symbols LFNG
Host Species Mouse
Immunogen LFNG (AAH14851, 1 a.a. ~ 250 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3955
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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