LY 294002 hydrochloride, Tocris Bioscience™

Catalog No. 11-305

Supplier: R&D Systems 1130/5

Description

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

LY 294002 hydrochloride is a prototypical PI 3-kinase inhibitor (IC50 values are 0.31, 0.73, 1.06 and 6.60 μM for PI 3-Kβ, PI 3-Kα, PI 3-Kδ and PI 3-Kγ respectively). Also inhibits other kinases including, CK2, mTOR, PLK1, PIM1 and PIM3. Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo. Suppresses proliferation of mESCs. Inhibits autophagic sequestration in rat hepatocytes.

Negative Control also available.

Greener Choice Claims

• Environmental benefits include:
• Ozone-Safe or Safe for the Ozone Layer

Specifications

Chemical Identifiers

• CAS: 934389-88-5
• Molecular Formula: C19H18ClNO3
• Molecular Weight (g/mol): 343.807
• InChI Key: OQZQSRICUOWBLW-UHFFFAOYSA-N
• Synonym: ly-294,002 hydrochloride, ly-294002 hydrochloride, ly 294002 hydrochloride, 2-4-morpholinyl-8-phenyl-4h-1-benzopyran-4-one hydrochloride, 2-morpholin-4-yl-8-phenylchromen-4-one hydrochloride, 2-morpholin-4-yl-8-phenyl-chromen-4-one, 2-morpholin-4-yl-8-phenylchromen-4-one,hydrochloride, 2-morpholino-8-phenyl-4h-chromen-4-one hydrochloride, 2-4-morpholinyl-8-phenyl-1 4h-benzopyran-4-one hydrochlorideShow MoreShow Less
• PubChem CID: 11957589
• IUPAC Name: 2-morpholin-4-yl-8-phenylchromen-4-one;hydrochloride
• SMILES: C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4.Cl

• Quantity: 5 mg
• Formula Weight: 343.81
• Percent Purity: >99%
• Chemical Name or Material: LY 294002 hydrochloride

Safety and Handling

Recommended Storage

Store at Room Temperature