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Ly-49G2 Monoclonal Antibody (eBio4D11 (4D11)), FITC, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

$165.00

Specifications

Antigen Ly-49G2
Clone eBio4D11 (4D11)
Concentration 0.5 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-985-1
Encompass_Preferred
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Invitrogen™
11578182
100 μg
Each of 1 for $165.00
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Description

Description

Description: The 4D11 monoclonal antibody reacts with Ly-49G2 (also known as LGL-1). The Ly-49 family of NK-cell receptors, members of the C-type lectin superfamily, are disulfide-linked type-II transmembrane protein homodimers with extracellular carbohydrate recognition domains, which bind to MHC class I alloantigens. The Ly-49 family members are expressed independently, such that an individual NK or T cell may display more than one class of Ly-49 receptor. Ly-49G2 is an inhibitory receptor expressed on subsets of natural killer (NK) cells, NK-T cells (in all strains tested), and on a population of memory CD8+ T cells (in C57BL/6 mice). The 4D11 antibody has been reported to cross react with the Ly-49AB6, Ly-49ABALB, and Ly-49T129/J inhibitory receptors and Ly-49LCBA/J activatingreceptors. The proportion of NK-T cells expressing Ly-49A and Ly-49G2 is higher in the thymus than in liver, and there is evidence that down-regulation of Ly-49 receptor expression is necessary for normal NK-T-cell development to occur. Applications Reported: This eBio4D11 (4D11) antibody has been reported for use in flow cytometric analysis. Applications Tested: This eBio4D11 (4D11) antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL.

Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells, while allowing them to attack infected or transformed cells in which class I molecules have been down-regulated. These inhibitory receptors are also expressed on subpopulations of mouse CD8+ T cells.
Specifications

Specifications

Ly-49G2
0.5 mg/mL
Monoclonal
Liquid
RUO
Q60654
Klra7
Primary
4°C, store in dark, DO NOT FREEZE!
Klra7
eBio4D11 (4D11)
Flow Cytometry
FITC
Rat
Mouse
16638
IgG2a κ
Affinity chromatography
Antibody
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SDS
Documents

Documents

Product Certifications

For Research Use Only.

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