MALT1 Antibody (SPM578), Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP2328720.2MG

Catalog No. NBP232872B

Description

MALT1 Monoclonal antibody specifically detects Antigen in Human samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry (Paraffin), Western Blotting.

Specifications

• Antigen: MALT1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA. with 0.05% Sodium Azide
• Gene Alias: caspase-like protein, DKFZp434L132, EC 3.4.22.-, MALT associated translocation, MALT lymphoma-associated translocation, MLT1, MLTMALT-lymphoma associated translocation, mucosa associated lymphoid tissue lymphoma translocation gene 1, mucosa-associated lymphoid tissue lymphoma translocation protein 1, paracaspase
• Host Species: Mouse
• Molecular Weight of Antigen: 93 kDa
• Quantity: 0.2 mg
• Research Discipline: Apoptosis, Cancer, Tumor Suppressors
• Gene ID (Entrez): 10892
• Target Species: Human
• Form: Purified

• Applications: Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
• Clone: SPM578
• Dilution: Western Blot 0.5-1ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 1-2ug/ml, Immunohistochemistry-Paraffin 0.5-1.0ug/ml
• Gene Accession No.: Q9UDY8
• Gene Symbols: MALT1
• Immunogen: Human MALT1 recombinant fragment (aa701-808)
• Purification Method: Protein A purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18)(q21;q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells.
• Content And Storage: Store at 4C.
• Isotype: IgG1 κ