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MAML3 Antibody (MAML3/1303), Novus Biologicals™
SDP

Catalog No. NBP247646B Shop All R&D Systems Products
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0.1 mg
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Catalog No. Quantity
NBP247646B 0.2 mg
NBP247646F 0.02 mg
NBP247646A 0.1 mg
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Catalog No. NBP247646B Supplier Novus Biologicals Supplier No. NBP2476460.2MG

Description

Mouse Monoclonal Antibody

MAML3 Monoclonal antibody specifically detects Antigen in Human samples. It is validated for Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin).

Specifications

Antigen MAML3
Applications Flow Cytometry, Immunohistochemistry (Paraffin), SDS-Page, Immunofluorescence
Classification Monoclonal
Clone MAML3/1303
Conjugate Unconjugated
Dilution Flow Cytometry 0.5-1ug/million cells, Immunohistochemistry-Paraffin 0.5-1.0ug/ml, SDS-Page, Immunofluorescence 0.5-1ug/ml
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Alias CAG/CTG 3, ERDA3, MAM-2, mam-3, mastermind-like 3 (Drosophila), mastermind-like protein 3, polyglutamine rich, trinucleotide repeat containing 3
Gene Symbols MAML3
Host Species Mouse
Immunogen Recombinant human MAML3 protein fragment
Purification Method Protein A or G purified
Quantity 0.2 mg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) 55534
Test Specificity MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jk; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgG1
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