MAML3 Antibody (MAML3/1303), Novus Biologicals™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NBP247646F	Novus Biologicals NBP2476460.02MG	0.02 mg
NBP247646A	Novus Biologicals NBP2476460.1MG	0.1 mg
NBP247646B	Novus Biologicals NBP2476460.2MG	0.2 mg

Description

MAML3 Monoclonal specifically detects MAML3 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: MAML3
• Dilution: Flow Cytometry 0.5-1ug/million cells, Immunohistochemistry-Paraffin 0.5-1.0ug/ml, SDS-Page, Immunofluorescence 0.5-1ug/ml
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Target Species: Human
• Gene Alias: CAG/CTG 3, ERDA3, MAM-2, mam-3, mastermind-like 3 (Drosophila), mastermind-like protein 3, polyglutamine rich, trinucleotide repeat containing 3
• Gene Symbols: MAML3
• Isotype: IgG1
• Purification Method: Protein A or G purified
• Test Specificity: MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jk; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.

• Clone: MAML3/1303
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), SDS-Page, Immunofluorescence
• Conjugate: Unconjugated
• Host Species: Mouse
• Research Discipline: Neuroscience
• Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
• Gene ID (Entrez): 55534
• Immunogen: Recombinant human MAML3 protein fragment
• Primary or Secondary: Primary
• Content And Storage: Store at 4C.