Mash1/Ascl1 Polyclonal Antibody, Rockland™

Goat Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-1577	Rockland Immunochemicals 600101MH4	100 μg
50-199-1578	Rockland Immunochemicals 600101MH4S	25 μL

Description

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This affinity purified antibody is directed against mouse Mash1/Ascl1. A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to mouse and rat, and 93% homology with human.

ASCL1 (also known as ASH1) is a basic helix-loop-helix transcription factor that is required for early development of the nervous system. Expressed in fetal brain, ASCL1 is essential for the proper development of autonomic neurons and for the survival of subsets of autonomic neurons. ASCL1 interaction with MEF-2A may regulate the expression of specific genes that are critical for the formation of distinct neuronal circuits within the central nervous system. The high level of ASCL1 expression in neuroendocrine tumors, such as medullary thyroid cancer, small cell lung cancer and lung cancer with neuroendocrine features may provide a useful marker for cancers with neuroendocrine features. Mapping to human chromosome 12, the ASCL1 gene contains a trinucleotide repeat region, making this locus a candidate for inherited disease.

Specifications

• Antigen: Mash1/Ascl1
• Applications: ELISA, Immunohistochemistry, Western Blot
• Conjugate: Unconjugated
• Host Species: Goat
• Target Species: Human, Mouse
• Gene Accession No.: P50553, Q02067
• Gene ID (Entrez): 17172, 429
• Primary or Secondary: Primary
• Product Type: Antibody

• Concentration: 1 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
• Gene Alias: achaete scute protein; achaete-scute complex homolog 1; achaete-scute complex homolog 1 (Drosophila); achaete-scute complex homolog-like 1; achaete-scute complex-like 1; achaete-scute complex-like protein 1; achaete-scute family bHLH transcription factor 1; Achaete-scute homolog 1; achaete-scute homolog 1-like; AI225900; ASCL1; ASH1; ASH-1; BHLHA46; Class A basic helix-loop-helix protein 46; HASH1; KMT2H; LOC100342114; mammalian achaete scute homolog 1; Mash1; Mash-1
• Gene Symbols: Ascl1
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Gene: Ascl1