MASTL Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-157-2450	Bethyl Laboratories, Inc IHC00638T	10 μL
50-157-2449	Bethyl Laboratories, Inc IHC00638	100 μL

Description

The recommended shelf life for this product is 1 year from date of receipt.

Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintece. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. Ota T., Nat. Genet. 36:40-45(2004). Deloukas P., Nature 429:375-381(2004). Beausoleil S.A., Nat. Biotechnol. 24:1285-1292(2006).

Specifications

• Antigen: MASTL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Alias: GREATWALL, GW, GWL, MAST-L, RP11-85G18.2, THC2, hGWL, greatwall protein kinase, microtubule-associated serine/threonine-protein kinase-like, serine/threonine-protein kinase greatwall
• Gene Symbols: MASTL
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody

• Applications: Immunohistochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q96GX5
• Gene ID (Entrez): 84930
• Immunogen: Between 550 and 600
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Gene: MASTL