MBD1 Monoclonal Antibody (OTI1A1), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA811766

Catalog No. 50-168-4238

Description

Methyl-CpG-binding domain protein 1 (MBD1) is a member of a family of mammalian proteins that specifically bind methylated regions of DNA. It is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). MBD1 acts as a transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Isoform 1 and isoform 2 can also repress transcription form unmethylated promoters.

Specifications

• Antigen: MBD1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9UIS9
• Gene Symbols: MBD1
• Immunogen: Human recombit protein fragment corresponding to amino acids 222-556 of human MBD1 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI1A1
• Conjugate: Unconjugated
• Gene: MBD1
• Gene Alias: CXXC3, PCM1, RFT
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4152
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid