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MCM4 Polyclonal Antibody, Bethyl Laboratories

Catalog No. p-7139994
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50-155-6947 20 μL
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Catalog No. 50-155-6947 Supplier Bethyl Laboratories, Inc Supplier No. A300125AT
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Description

Goat Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

The protein encoded by this gene is one of the highly conserved mini-chromosome maintece proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

Specifications

Antigen MCM4
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene MCM4
Gene Accession No. P33991, P49717
Gene Alias CDC21, CDC54, P1-CDC21, hCdc21, CDC21 homolog, DNA replication licensing factor MCM4, MCM4 minichromosome maintece deficient 4, homolog of S. pombe cell devision cycle 21, minichromosome maintece deficient 4
Gene Symbols MCM4
Host Species Goat
Immunogen Between 325 and 375
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17217, 4173
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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