Invitrogen™ MEI1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA561916

Catalog No. PIPA561916

Description

Immunogen sequence: HMKEKFSKKL ASSSFIRLTL ELKARFCSGL SHSALNQVCS NFLYYMCLNL LSAPEKTGPP SKEELSAVSE LLQHGLPQIS SRS Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 81%.

The predominant cause of spermatogenic arrest of meiosis is the failure of homologous chromosomes to accurately synapse. MEI1 (Meiosis inhibitor protein 1), also designated Meiosis defective protein 1, is a 1274 amino acid protein that is likely required for the formation of genetically programmed double-strand breaks, the first step in the initiation of meiosis. With predominant expression in testis, it is likely that defects of the gene encoding MEI1 results in male infertility. Interestingly, studies show that genetic variation in the MEI gene possibly predisposes European Americans but not Israeli men to infertility by meiotic arrest. Human MEI1 shares 79% sequence similarity with its mouse homolog. There are seven isoforms of MEI1 that are produced as a result of alternative splicing events.

Specifications

• Antigen: MEI1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MEI1
• Gene Alias: 4932408F18Rik; MEI1; meiosis defective 1; meiosis defective protein 1; meiosis inhibitor 1; meiosis inhibitor protein 1; meiotic double-stranded break formation protein 1; SPATA38; spermatogenesis associated 38
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 150365
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q5TIA1
• Gene Symbols: MEI1
• Immunogen: Recombinant protein corresponding to Human MEI1. Recombinant protein control fragment (Product #RP-95369).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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